Synthesis and cytotoxicity of new 4-aza-2,3-didehydropodophyllotoxins

Five new 4-aza-2,3-didehydropodophyllotoxins were synthesized by a straightforward multi-component reaction in the hope of finding structures with interesting anticancer activity. The “one-pot” synthesis process is developed to increase performance as well minimize steps involved. obtained compounds podophyllotoxin frame have corresponding yields 60-83%. demonstrated comparable cytotoxicity against Hep-G2, MCF7cell lines an IC50 value 52.2 - 261.2 µM ellipsitine positive control.